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Tuesday, January 27, 2009

Anti-Androgens In Water Decrease Male Fertility

Men's Fertility Affected By Water Pollution

It has been widely reported that there are chemical toxins which can mimic estrogens.
My site: www.getpregnantover40.com
This has an affect on both men and women. In addition, the following article talks about new findings which show there are also chemicals which are "anti-androgenic which also block testosterone. All of this together can lead to male infertility. Read more:

River Pollutants Linked To Male Infertility (www.independent.co.uk)

From the article:

Scientists have identified a group of river pollutants that are able to stop testosterone from working. These anti-androgens have been linked with the feminisation of fish in British rivers and could be affecting the development of male reproductive organs in humans, it found.

The study has established a link between anti-androgens released into rivers from sewage outflows and abnormalities in wild fish where males develop female reproductive organs. It is the first time that anti-androgens and hermaphrodite fish have been linked in this way.

Until now it was thought another class of chemicals, which mimic the effect of the female sex-hormone oestrogen, were responsible for sex-changed fish. However the latest study indicates that the cause may be the result of a rather more complicated interaction taking place between different pollutants.

Dr Susan Jobling of Brunel University, is one of the authors of the study carried out with colleagues from Exeter and Reading universities and the Centre of Ecology and Hydrology. She said: "We have identified a new group of chemicals in our study on fish, but we do not know where they are coming from or what they are. We've only been able to measure their testosterone-blocking potential."

For the study, published in thejournal Environmental Health Perspectives, the scientists analysed anti-androgenic activity in samples of river water taken near 30 sewage outflows. They were able to demonstratestatistically that this activity could be linked with hermaphrodite fish found in the same rivers.

Dr Jobling said that there are several chemicals in widely-used pharmaceuticals and pesticides that are known to have anti-androgenic activity. They included flutamide and cyproterone, used to treat prostate cancer, and several compounds found in agricultural pesticides.

The scientists detected relatively high levels of anti-androgenic chemicals near sewage outflows – suggesting they came from domestic sources. One possibility is that drugs excreted from the body may end up in rivers. However the scientists have not discounted the idea that anti-androgens may also be seeping into rivers as run-off from agricultural land.

Scientists first detected sex-change fish in British rivers more than 20 years ago. During the same period, medical researchers found that human sperm counts have been falling in several countries over a period of 30 years or more. This has been matched by a corresponding rise in other male reproductive problems, such as the congenital condition testicular dysgenesis, which can affect fertility.

Monday, January 26, 2009

Endometriosis Begins At Birth?

I've written before about the many theories of endometriosis. This article talks about how there might be a couple of factors - babies may be exposed to environmental toxins before birth which may predispose them to the condition. Read more:

www.medindia.net

From the article:

The study led by Serdar Bulun, M.D., George H. Gardner Professor of Clinical Gynecology at Northwestern University’s Feinberg School of Medicine, have discovered key epigenetic abnormalities in endometriosis and identified existing chemicals that now help treat it.

These abnormalities result from epigenetic defects that occur very early on during embryonic development and may be the result of early exposure to environmental toxins

One of the abnormalities he discovered is the presence of the enzyme aromatase - which produces estrogen - in endometriosis, the diseased tissue that exists on pelvic organs and mimics the uterine lining.

As a result, women with endometriosis have excessive estrogen in this abnormal tissue found on surfaces of pelvic organs such as the ovaries.

Bulun found the protein SF1 that produces aromatase, which is supposed to be shut down, is active in endometriosis.

"Estrogen is like fuel for fire in endometriosis. "It triggers the endometriosis and makes it grow fast," Bulun said.

Bulun launched clinical trials in testing aromatase inhibitors currently used in breast cancer treatment - for women with endometriosis.

The drug blocks estrogen formation and secondarily improves progesterone responsiveness.

"We came up with a new treatment of choice for post-menopausal women with endometriosis," Bulun said. Moreover, treatment with an aromatase inhibitor is a very good option for premenopausal women with endometriosis not responding to existing treatments, he said

Wednesday, January 21, 2009

Infertility, Miscarriage and Pre-eclampsia Linked To Inflammation

Infertility And Miscarriage, How Inflammation May Be To Blame

 "Inflammation" seems to be the new buzzword within the healthcare community.
My site:www.getpregnantover40.com 
It has been associated with many disorders including premature aging, autoimmune diseases and now with infertility. Here is an interesting article that links inflammation with infertility, miscarriage and pre-eclampsia. Read more:

(prenatal-health.suite101.com)

From the article:

Recent Study Links Miscarriage and Infertility to Pre-Eclampsia
The Norwegian Mother and Child Cohort Study (MoBa) involved 20,846 first time mothers who self-reported on miscarriage, infertility and complications of pregnancy. Pre-eclampsia was determined from the Medical Birth Registry of Norway. Women who had experienced either miscarriage or infertility had an increased risk of subsequent pre-eclampsia. Those with both prior miscarriage and infertility had more than double the risk of subsequent pre-eclampsia.

Pre-eclampsia Is a Symptom of Inflammation
Pre-eclampsia is a potentially dangerous increase in blood pressure and loss of protein into the urine, proteinuria. Further increase in these symptoms without prompt treatment, could result in eclampsia, seizure. Since pre-eclampsia normally develops during the third trimester, the usual treatment is induction of birth. There is increasing evidence that pre-eclampsia is brought on by increasing oxidative stress, depletion of natural anti-oxidants and depletion of omega-3 fatty acids. It appears that pre-eclampsia can be treated as an omega-3 fatty acid deficiency and inflammation.

Comparison of Normal and Pre-eclamptic Women Reveals Inflammation
In a recent Indian study, blood from normal and pre-eclamptic women was analyzed for symptoms of oxidative stress. Both maternal and umbilical cord samples were analyzed. Blood from pre-eclamptic women showed lower omega-3 fatty acids, higher omega-6 to omega-3 fatty acid ratios, higher oxidative stress and depleted natural antioxidants.

Monday, January 19, 2009

Mountain Biking Connected To Infertility and Testicular Cancer

Men's Fertility, Sperm Affected By Mountain Biking

This should be no surprise to most of my readers: mountain biking may not be the best thing for the man in your life if you're trying to conceive.
My site: www.getpregnantover40.com
 Not only can it affect fertility, but it may also be associated with an increased risk of testicular cancer. Lance Armstrong came to mind when I read this (I realize he's not a mountain biker, but it seems like it would affect him in the same way). This article discusses the actual research behind biking and male fertility. Read more:


Mountain biking connected to infertility (www.bio-medicine.org)

From the article:

In his presentation, Dr. Frauscher said more than 10 million Americans mountain bike, a number that has risen in recent years. While the sport has been associated for some time with erectile dysfunction, this study looked at whether there is a link between the sport and reduced fertility.

Semen analysis was performed on the bikers and non-bikers and the two groups were compared. Dr. Frauscher reported at today's meeting that bikers had a sperm count of 22 million/ml and 30 percent motility. Non-bikers showed a sperm count of 48 million/ml and a motility of 50 percent. According to him both are statistically significant.

Further analysis by Dr. Frauscher and colleagues suggests the reduction in count and motility may be related to vascular damage caused by continuous trauma to the testicles. The ultrasound images taken during the study also indicate mountain bikers have an increased risk for calcifications in the testicles and other problems, which may increase a man's risk for testicular cancer.

Dr. Frauscher propose that men who mountain bike use a bike with a shock absorber as well as padded cushions and shorts to reduce the amount of trauma inflicted on the testicles.

Monday, January 12, 2009

Asherman's Syndrome, Uterine Abnormalities and Fertility

picture: www.medicinenet.com/www.medterms.com

I did have a couple of D&C's after a few of my miscarriages. I was always a little worried about what it might do to my uterus because the instrument they use really does look scary (it's very sharp at the end). I'm sure most women who have D&C's have no problems afterwards, however, according to this article, it can leave scar tissue which could hurt your ability to get pregnant (Asherman's Syndrome). Read more about this condition and other uterine abnormalities:

Uterine Factors
How Abnormalities of the Uterus Contribute to Infertility
By Gwen Morrison
www.preconception.com


From the article:

The National Infertility Association defines Asherman's syndrome as the presence of scar tissue in the uterine cavity (intrauterine adhesions). In a severe case, where the entire uterine cavity is scarred, the woman does not menstruate. Where the scarring is less severe, women may have light periods.
"Asherman's syndrome is basically a loss of the normal lush lining of the uterine cavity," Dr. Pollycove says. "Most often this is after an endometrial curettage (a scraping procedure to empty the cavity of pregnancy tissue; post-spontaneous, incomplete or elective abortion). Scar tissue can form and cause an inhospitable environment of he uterine cavity."

Friday, January 09, 2009

Fertility Treatments Double and Quadruple Chance Of Structural Birth Defects


I've been reading for years about the possibility of birth defects as a result of fertility treatments. Some sources show a clear connection, others dispute it. I realize some couples must undergo fertility treatments to have a child, however, I think everyone should make decisions taking all information into account. Since I underwent fertility treatments quite a few years ago, I'm not sure this information was known. I can say for sure, I was never warned about the possibility of birth defects. Here is a very recent article from Novemer '08 about how certain structural defects are more common with fertility treatments. If you do choose to go through fertility treatments, the risk of defects is still small and the vast majority of babies are born perfectly normal, but again, it never hurts to have all the information before going through a procedure. Read more:

More birth defects seen with fertility treatment (www.sfgate.com)

From the article:

(11-17) 18:15 PST SAN FRANCISCO -- Infants conceived as a result of infertility treatments are two to four times more likely to have certain types of birth defects than children conceived naturally, according to one of the nation's largest studies on the issue.

The defects, which frequently can be surgically treated, range from heart anomalies to cleft lips to gastrointestinal disorders.

"None of these are lethal," said Dr. Jennita Reefhuis, an epidemiologist with the federal Centers for Disease Control and Prevention and one of the study's authors. "The individual risk of birth defects is still very small. But it is very important for couples who are considering artificial reproductive technology to have full disclosure."

More and more couples unable to conceive naturally have turned to assisted reproductive technology in recent years; according to one study, nearly 12 percent of women in the United States have undergone infertility procedures.

About 1 percent of all births in the United States now occur as a result of infertility treatment - that represents a doubling since 1996. More than 134,000 such procedures were performed in 2005 in the United States, resulting in about 52,000 births. The procedures are generally considered to involve higher risks, but the study - released Monday - is among the first in the country to analyze an association between infertility treatments and major structural birth defects.

It found that there was twice the risk of heart defect, more than twice the risk of cleft lip, and more than four times the risk of some gastrointestinal defects when compared with babies conceived without fertility treatments. For example, the risk of a baby in the United States being born with a cleft lip with or without a palate is about 1 in 950, but the study found that the risk is 1 in 425 for babies conceived through infertility treatments.

Wednesday, January 07, 2009

Fertility and HPV

Can HPV Hurt Your Chances Of Getting Pregnant?

It seems like there's been an increased awareness of the Human papillomavirus since the new vaccine has come out.
My site: www.getpregnantover40.com

It's been widely advertised that HPV can be a cause of cervical cancer, but can it affect fertility and pregnancy? Here is an article that explains more:

http://www.merchantcircle.com/business/Alejandra.Turmero.MD.Obstetrics.And.Gynecology.305-274-3130/newsletter/88226

From the article:

"HPV has no direct link to fertility," Dr. Fink says. "It is extremely common among reproductive-aged women, and fortunately we have not found an effect on the ability of a woman to conceive related to having HPV or pre-cancers. It is a very common question, however. In fact, 'Will this affect [my] having babies?' is often the first question I am asked when performing a colposcopy. And the answer is, generally, no."
That being said, gynecologists are always cautious with a woman's cervix. The cervix is the opening to the uterus and is integral to pregnancy. Treatments of the cervix must necessarily take this into consideration. Dr. Fink says the two common treatments for pre-cancers are cryotherapy and cone biopsies. Cryotherapy is the freezing of superficial cells in an effort to rid the cervix of those pre-cancer cells. This can have an effect on the mucous-producing cells of the cervix that are related to fertility.

Cone biopsies are reserved for so-called "high-grade" pre-cancers and actually remove a small portion of the cervix containing the diseased tissue. Too large a cone biopsy or the need for multiple procedures over a woman's life due to recurrent high-grade pre-cancers can result in a weakness of the tissue when it comes to holding a pregnancy inside. This is known as an incompetent cervix.

Tuesday, January 06, 2009

TCM AND CHINESE FERTILITY MASSAGE

See "Fertility Bodywork"(getpregnantover40.com) which has a segment on fertility self massage which incorporates acupressure, reflexology and abdominal massage.

Self fertility massage can help increase circulation of the reproductive system and increase oxygenated blood.  The uterus also can benefit from the uterine lift which can put the uterus back into position and massage may break up small blockages "cobwebs" that may be hindering your ability to conceive.


Fertility Massage for Treating Specific Causes of Infertility

Along with the above two approaches, some fertility massages involve other sciences like reflexology. During such fertility massages, pressure is applied to certain points on the feet. In reflexology, it is understood that every point on the feet has a controlling action on a specific organ within the body. Thus, when such pressure points are gently massaged, the related reproductive organ is stimulated. This is a recommended way to treat infertility caused by specific organs. Examples of such fertility massages include:
  • Ovary Massages—ovaries are often suffocated due to an impaired ovulation cycle wherein they suffer from a lack of nutrients and oxygenated blood. Fertility massages using reflexology principles are particularly useful for restoring disturbed ovulation and menstruation cycles.
  • Uterine Massages—the uterus is located within the pelvic cavity. It is the site for the fertilization of the egg. Fertility massage helps to stimulate the natural healing process within a uterus that is too dry, tilted or compressed by a constipated


Read more: http://www.fertilityproregistry.com/article/fertility-massage-how-it-works-to-boost-fertility.html#ixzz2CdWUoCdh



Fertility Massage for Treating Specific Causes of Infertility

Along with the above two approaches, some fertility massages involve other sciences like reflexology. During such fertility massages, pressure is applied to certain points on the feet. In reflexology, it is understood that every point on the feet has a controlling action on a specific organ within the body. Thus, when such pressure points are gently massaged, the related reproductive organ is stimulated. This is a recommended way to treat infertility caused by specific organs. Examples of such fertility massages include:
  • Ovary Massages—ovaries are often suffocated due to an impaired ovulation cycle wherein they suffer from a lack of nutrients and oxygenated blood. Fertility massages using reflexology principles are particularly useful for restoring disturbed ovulation and menstruation cycles.
  • Uterine Massages—the uterus is located within the pelvic cavity. It is the site for the fertilization of the egg. Fertility massage helps to stimulate the natural healing process within a uterus that is too dry, tilted or compressed by a constipated colon.


Read more: http://www.fertilityproregistry.com/article/fertility-massage-how-it-works-to-boost-fertility.html#ixzz2CdWL8f5W

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